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Mechanism of action of vancomycin nephrotoxicity in the renal proximal tubule cells. Created in BioRender.

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Protamine protects against vancomycin-induced kidney injury

doi: 10.1128/aac.01236-24

Figure Lengend Snippet: Mechanism of action of vancomycin nephrotoxicity in the renal proximal tubule cells. Created in BioRender.

Article Snippet: The agents used for treatments were clinical grade Protamine Sulfate Injection (Fresenius Kabi, Lake Zurich, IL, USA); clinical grade Vancomycin HCl (Hospira, Lake Forest, IL, USA); Omnipaque (iohexol) injection (GE Healthcare, Marlborough, MA, USA); and Normal Saline (Veterinary 0.9% sodium chloride injection USP; Abbott Laboratories, North Chicago, IL, USA).

Techniques:

Putative mechanism of megalin inhibition by protamine and the protective effects from vancomycin nephrotoxicity. Created in BioRender.

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Protamine protects against vancomycin-induced kidney injury

doi: 10.1128/aac.01236-24

Figure Lengend Snippet: Putative mechanism of megalin inhibition by protamine and the protective effects from vancomycin nephrotoxicity. Created in BioRender.

Article Snippet: The agents used for treatments were clinical grade Protamine Sulfate Injection (Fresenius Kabi, Lake Zurich, IL, USA); clinical grade Vancomycin HCl (Hospira, Lake Forest, IL, USA); Omnipaque (iohexol) injection (GE Healthcare, Marlborough, MA, USA); and Normal Saline (Veterinary 0.9% sodium chloride injection USP; Abbott Laboratories, North Chicago, IL, USA).

Techniques: Inhibition

Comparison of KIM-1 across drug treatment groups by day

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Protamine protects against vancomycin-induced kidney injury

doi: 10.1128/aac.01236-24

Figure Lengend Snippet: Comparison of KIM-1 across drug treatment groups by day

Article Snippet: The agents used for treatments were clinical grade Protamine Sulfate Injection (Fresenius Kabi, Lake Zurich, IL, USA); clinical grade Vancomycin HCl (Hospira, Lake Forest, IL, USA); Omnipaque (iohexol) injection (GE Healthcare, Marlborough, MA, USA); and Normal Saline (Veterinary 0.9% sodium chloride injection USP; Abbott Laboratories, North Chicago, IL, USA).

Techniques: Comparison

Comparison of KIM-1 across days within treatment groups with baseline as a comparator

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Protamine protects against vancomycin-induced kidney injury

doi: 10.1128/aac.01236-24

Figure Lengend Snippet: Comparison of KIM-1 across days within treatment groups with baseline as a comparator

Article Snippet: The agents used for treatments were clinical grade Protamine Sulfate Injection (Fresenius Kabi, Lake Zurich, IL, USA); clinical grade Vancomycin HCl (Hospira, Lake Forest, IL, USA); Omnipaque (iohexol) injection (GE Healthcare, Marlborough, MA, USA); and Normal Saline (Veterinary 0.9% sodium chloride injection USP; Abbott Laboratories, North Chicago, IL, USA).

Techniques: Comparison